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Trypsin

Trypsin possesses anti-inflammatory as well as potent proteolytic properties which can be used in molecular research. For the treatment of wound healing, Trypsin may be useful in removing dead tissue. Localisation of  tissue damage, a cardinal aspect of the inflammatory process, is in part due to fibrin deposition, with the consequent formation of a mechanical barrier (connective tissue) in the tissue spaces. Trypsin helps to break these blockages off and allows passing of blood and nutrients to the inflamed area.

Trypsin is extracted from both bovine or porcine pancreas and pancreatic juices using multiple precipitation, fractionation, and filtration steps. The process from extraction of pancreas to final product takes approximately 5 weeks, with a few grams of pure Trypsin being produced from one tonne of pancreas.

Trypsin is obtained by activation of its precursor zymogen (trypsinogen) by Trypsin itself, certain mold proteinases and by Enterokinase.

Our procedures, that have been developed and optimised over many years and batches, ensure the highest quality, stability and batch-to-batch consistency, providing reagent manufacturers with Trypsin products of proven performance. Trypsinogen is largely present in animal pancreas and in certain bacteria. The product can be tested as per the USP/EP/BP test methodology.

 

  Product Sheet        Analytical Procedure

Grade Product Specification
Trypsin > 2,500 U/mg material
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Trypsin / Chymotrypsin 1:1 >1000 :1000 NF U/mg material
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Trypsin / Chymotrypsin 6:1 >2200-2760: 365-460 NF U/mg material
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